Change of Adviser
29 November 2023
Oxford, UK. GENinCode Plc (AIM: GENI), the predictive genetics company focused on the prevention of cardiovascular disease, is pleased to announce the appointment of Cavendish Capital Markets Limited as Nominated Adviser and Broker with immediate effect.
For more information visit www.genincode.com
GENinCode Plc | www.genincode.com or via Walbrook PR | |
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Matthew Walls, CEO | ||
Cavendish Capital Markets Limited (Nomad and Broker) | Tel: +44 (0)20 7397 8900 | |
Giles Balleny / Dan Hodkinson (Corporate Finance) | ||
Nigel Birks (ECM) Dale Bellis / Michael Johnson (Sales) |
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Walbrook PR Limited | Tel: 020 7933 8780 or | |
Anna Dunphy / Louis Ashe-Jepson / Phillip Marriage | or genincode@walbrookpr.com |
About GENinCode:
GENinCode Plc is a UK based company specialising in genetic risk assessment of cardiovascular disease. Cardiovascular disease is the leading cause of death and disability worldwide.
GENinCode operates business units in the UK, Europe through GENinCode S.L.U, and
in the United States through GENinCode U.S. Inc.
GENinCode predictive technology provides patients and physicians with globally
leading preventive care and treatment strategies. GENinCode genetic tests
combine clinical algorithms and bioinformatics to provide advanced patient risk
assessment for coronary heart disease.
About Cardiovascular Disease (CVD):
Heart and circulatory disease also known as cardiovascular disease (CVD) is the
leading cause of death globally, taking an estimated 17.9 million lives
each year, with Coronary Heart Disease (CHD) representing the leading
cause of death for men, women, and people of most
racial and ethnic groups in the United States. CVD is a group of disorders
of the heart and blood vessels that include coronary heart disease,
cerebrovascular disease, rheumatic heart disease and other conditions. More than
four out of five CVD deaths are due to heart attacks and strokes, and one third
of these deaths occur prematurely in people under 70 years of age. By 2030
the global cost of CVD is set to rise from approximately US$863
billion in 2010 to US$1,044 billion and is both a major health issue and global
economic burden.
Cardiovascular disease, causes a quarter of all deaths in the UK and is the
largest cause of premature mortality in deprived areas and is the single biggest
area where the NHS can save lives over the next 10 years. CVD is largely
preventable, through lifestyle changes and a combination of public health and
action on smoking and tobacco addiction, obesity, tackling alcohol misuse and
food reformulation.
The most important behavioural risk factors of heart disease and stroke are
unhealthy diet, physical inactivity, tobacco use and harmful use of alcohol. The
effects of behavioural risk factors may show up in individuals as raised blood
pressure, raised blood glucose, raised blood lipids, and overweight and obesity.
These “intermediate risks factors” can be measured in primary care facilities
and indicate an increased risk of heart attack, stroke, heart failure and other
complications.
Identifying those at highest risk of CVDs and ensuring they receive appropriate
treatment can prevent premature deaths. Access to noncommunicable
disease medicines and basic health technologies in all primary health care
facilities is essential to ensure that those in need receive treatment and
counselling.
The current standard of care for assessing cardiovascular risk is primarily based on traditional clinical risk factors such as age, sex, smoking, body mass, blood pressure and cholesterol levels from which individuals are categorised as being at low, moderate or high risk of a CVD event (e.g heart attack/myocardial infarction). This categorisation is imperfect as CVD events frequently occur in those thought to be at low or moderate risk. The size of the populations at low or moderate risk are much larger than those at high or very high risk so whilst the relative risk of a CVD event may be small, the absolute number of CVD events in low and moderate risk populations is much greater than the number of events in higher risk categories.
Clinicians have for many years recognised the importance of prior CVD events within the families of their patients because genetic factors contribute to the development of atherosclerosis and a patient's family history has become a surrogate for their inherited genetic risk. In recent years, with the advances of genomics, it has proved possible to add genetic profiling to conventional CVD risk factors, the combination of the two (genetics and conventional clinical risk factors) enhancing the predictive capability of patient risk thereby resulting in a personalised and preventive approach to CVD.